A Study to Determine Dose Safety Tolerability and Efficacy of CC-220 Monotherapy and in Combination With Other Treatments in Subjects With Multiple Myeloma

Study Overview

This is a multicenter, multi-country, open-label, Phase 1b/2a dose-escalation study consisting of two parts: dose escalation (Part 1) for CC-220 MonoT, CC-220 in combination with DEX, CC-220 in combination with DEX and DARA, CC-220 in combination with DEX and BTZ and CC-220 in combination with DEX and CFZ; and the expansion of the RP2D (Part 2) for CC-220 MonoT, CC-220 in combination with DEX (DoubleT) for Relapsed Refractory Multiple Myeloma and CC-220 in combination with DEX and BTZ for Newly Diagnosed Multiple Myeloma.

Study Description

A PHASE 1B/2A MULTICENTER, OPEN-LABEL, DOSEESCALATION STUDY TO DETERMINE THE MAXIMUM TOLERATED DOSE, ASSESS THE SAFETY AND TOLERABILITY, PHARMACOKINETICS AND PRELIMINARY EFFICACY OF CC-220 MONOTHERAPY, IN COMBINATION WITH DEXAMETHASONE, AND IN COMBINATION WITH DEXAMETHASONE AND DARATUMUMAB OR BORTEZOMIB IN SUBJECTS WITH RELAPSED AND REFRACTORY MULTIPLE MYELOMA

  • ClinicalTrials.gov Identifier: NCT02773030
  • Protocol Number: 19-054
  • Principal Investigator: Jacalyn Rosenblatt

Recruitment Status

Open

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