Testing the Addition of a New Anti-cancer Drug Venetoclax to Usual Chemotherapy for High Grade B-cell Lymphomas

Study Overview

This phase II/III trial tests whether it is possible to decrease the chance of high-grade B-cell lymphomas returning or getting worse by adding a new drug, venetoclax to the usual combination of drugs used for treatment. Venetoclax may stop the growth of cancer cells by blocking a protein called Bcl-2. Drugs used in usual chemotherapy, such as rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax together with usual chemotherapy may work better than usual chemotherapy alone in treating patients with high-grade B-cell lymphomas, and may increase the chance of cancer going into remission and not returning.

Study Description

RANDOMIZED PHASE II/III STUDY OF VENETOCLAX (ABT 199) PLUS CHEMOIMMUNOTHERAPY FOR MYC/BCL2 DOUBLE-HIT AND DOUBLE EXPRESSING LYMPHOMAS

  • ClinicalTrials.gov Identifier: NCT03984448
  • Protocol Number: 19-815

Recruitment Status

Open

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