The IDEA Study (Individualized Decisions for Endocrine Therapy Alone)
Brief description of study
This study will collect rates of local/regional recurrence in select patients who do not
receive radiation treatment after lumpectomy surgery. These women must be postmenopausal;
have hormone receptor-positive, Her2-negative tumors; have Oncotype-DX RS less than or equal
to 18; and plan to receive endocrine therapy. In this way, this study seeks to collect
prospective data supporting the idea that this is a population at sufficiently low risk of
local/regional recurrence that omission of adjuvant radiation might be a reasonable option.
Clinical Study Identifier: NCT02400190
Detailed Study Description
This study's primary aim is to determine rates of recurrence with the innovative approach of
considering tumor biology to select patients who may avoid radiation, with restriction of
eligibility to women aged 50-69 with hormone-sensitive, Her2-negative tumors with
Oncotype-DX RS = 18 who plan to receive endocrine therapy. In this way, this study seeks to
collect prospective data supporting the idea that this is a population at low risk of LRR in
whom omission of adjuvant radiation is reasonable.