Clinical Trials & Research Studies

Study of bb2121 in Multiple Myeloma

Brief description of study

Study CRB-401 is a 2-part, non-randomized, open label, multi-site Phase 1 study of bb2121 in adults with relapsed/refractory multiple myeloma (MM).

Clinical Study Identifier: NCT02658929

Detailed Study Description

Part A of the study will enroll adults with multiple myeloma using a 3+3 dose escalation approach. An expansion cohort will be enrolled following dose selection. Following consent, enrolled subjects will undergo a leukapheresis procedure to collect autologous mononuclear cells for manufacture of investigational drug product (bb2121). Following manufacture of the drug product, subjects will receive lymphodepletion prior to bb2121 infusion. All subjects will then be followed for up to 24 months in Study CRB-401. All subjects who complete the study, as well as those who withdraw from the study after receiving bb2121 for reasons other than death or meeting the early termination criteria, will be asked to continue to undergo long-term follow-up in a companion study LTF-305 for up to 15 years after their last bb2121 infusion, with a focus on long-term safety and efficacy.

Contact research investigator to learn more about this study by filling out the form below.

To: Research Study Investigator
Subject: I am interested in participating in your Research Study
Dear Investigator,
I'm interested in learning more about and participating in your research study named: Study of bb2121 in Multiple Myeloma
Included below is some of my health information:
  1. Condition = Multiple Myeloma
I am hoping to hear back from you and discuss details of the study

By clicking "Contact Research Team", your contact information will be sent securely to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.